Sharko

POM TR. 033 324 441
(Distribution Permit Number from Board of Drug and Food Control the Republic of Indonesia)

Pharmacology

is a freeze dried purified extract of specific part of fresh shark cartilage. The extract contains proteoglycan and specific proteins with angiogenesis inhibitor activities to prevent nutrition and oxygen delivery to the tumor/cancer cells. As a complementary therapy in cancer, shark cartilage extract is beneficial for:

• preventing and reducing cancer growth
• shrinking cancer volume
• preventing metastasis

* for detailed information, please see product application

Composition

• Capsule

• Shark cartilage extract300mg
• Filler up to150mg

Indication

• As a complementary therapy against cancer
• As a complementary therapy against psoriasis

Contraindication

• Pregnancy and lactation
• Pre and post surgery patient
• Children under 18 years

Precaution

• Coronary Heart Disease

Warning

• Stop using when undesirable symptoms occurred. Please consult your doctor
• Keep away from children

Dose

• Capsule : 1 capsule, 3 times a day

Administration

• Capsule : ½ hour before or 1 hour after meals

Storage

• Keep in dry and cool place

Packaging

• Capsule : Box of bottle, 30 capsules @ 300 mg shark cartilage extract

Description : Each capsule contains 300 mg of extract from shark cartilage

 Download PDF

A.  as Complementary Therapy in Cancer

Cancer is a dangerous disease that is characterized by the abnormality and uncontrollability of the cell growth, which is able to metastases (spread) to many organs. Due to its characteristics, cancer often results in death. Another term for cancer is “malignant tumor”. There are two types of tumor: benign (non-cancerous tumors) and malignant (cancerous tumors).The differences between both types are the ability to spread to many organs.

A malignant tumor is able to invade and metastasize to other organs.(1) Cancer cells need angiogenesis (the growth of new blood vessels from pre-existing blood vessels) to supply oxygen and nutrition which support their growth and to metastasize. Angiogenesis starts with cancer hypoxia condition that stimulates Vascular Endothelial Growth Factor (VEGF) production. VEGF will bind to VEGF Receptor-2 (VEGFR-2) in endothelial cells (EC), then promotes proliferation, differentiation and migration of EC to form new branch of blood vessels (angiogenesis). Another element that plays an important role in angiogenesis is Matrix Metalloproteinases (MMPs). MMPs will degrade the extracellular matrix (ECM) of basement membrane in order to lay down new blood vessels.⁽²⁾

Fig.1. Mechanism of Action of SCE as an Angiogenesis Inhibitor

 is isolated from shark cartilage. This extract contains proteoglycan and many proteins with angiogenesis inhibitor activities to prevent nutrition and oxygen delivery to the tumor/ cancer cells.

Fig.2. Bioactive Substances of 

The mechanism of shark cartilage extract (SCE) as angiogenesis inhibitor is: ^(3,4)

If angiogenesis can be prevented, tumor cells will starve and expected outcomes will be:

1. Prevention and reduction of cancer growth
2. Shrinkage in cancer volume
3. Prevention of metastasis

Due to its specific property as an angiogenesis inhibitor in cancer neovascularization,  is used as complementary therapy against cancer.

B. as a Complementary Therapy for Psoriasis

Psoriasis is a chronic inflammatory disease characterized by hyperproliferation of keratinocytes. Body areas that are usually affected are scalp, nails, elbows, knees, and the back region. Chronic inflammation in psoriasis stimulates angiogenesis and collagen degradation. Collagen degradation results in impaired normal skin growth and hyper proliferation of keratinocytes which form psoriatic plaque on the body surface.⁽⁵⁾  with its angiogenesis inhibitor activity, is used as a complementary therapy against psoriasis.

 Download PDF